Wednesday, December 9, 2009

New Genetic Link for Vitamin D and Heart Health

And now comes more genetic proof that Vitamin D is an important heart health player. Once it became established that a "Vitamin D receptor" existed in the heart it was only a matter of time before researchers began teasing out why nature put it there.

New research shows that a gene variant of CYP27B1, which blocked production of an enzyme responsible for Vitamin D activation, accounted for a greater than two-fold risk for congestive heart failure (odds ratio 2.14, 95% CI 1.05-4.39). For a quick stats lesson on all that numeric gobbledygook it means that the researchers were "confident" that if they repeated their research 20 times they would get a result showing a increased risk of anywhere from 1.05 to 4.39 in 19 of the trials (95% of 20). The 95% figure is considered the minimum confidence threshhold for accepting a statistical result as valid. You can also look at the "confidence interval" (CI). If the interval does not include "1" (no risk difference) you are fairly certain your experiment determined a greater risk (a range above 1) or a lower risk (a range below 1). We can decipher "odds ratio" another day!

Of note was that a single SNP (the C allele of SNP rs4646536 for all you gene freaks out there like me) was the culprit. The large NIH VITAL Trial will provide more definitive data on both Vitamin D and Omega-3 links to heart disease when it is completed sometime in 2014. Until at least then, I will be taking my 8000IU of Vitamin D (what I need to hit a blood level of 60ng/dL - everyone is different).

Looking out for your heart health,


HeartHawk

22 comments:

vitamine b6 said...

Good information!An insufficient supply of vitamin D can be important in the emergence of chronic heart failure.Vitamin D plays an important role in regulating the calcium concentration in the body.Regular intake of rich food in vitamin D would certainly do no harm to health.

Highest CD Rates said...

This is a great information for me. I was only aware of the fact that deficiency of Vitamin D could cause bones problem. This is very knowledgeable article.

Anna said...

Previous research showed that mutations that inactivate the gene reduce the conversion of vitamin D into an active hormone."This study is the first indication of a genetic link between vitamin D action and heart disease," Simpson said in a news release from the University of Michigan."If subsequent studies confirm this finding and demonstrate a mechanism, this means that, in the future, we may be able to screen earlier for those most vulnerable and slow the progress of the disease.

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And now the DNA evidence that more vitamin D is an important player in heart health. Once it was established that vitamin D receptor in the heart there was only a matter of time before researchers have begun to mock.

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The gene responsible for the outbreak of vitamin D and high blood pressure version, new research shows is related to the development of global heart failure. Vitamin D, cardiovascular health outcomes research, to confirm the offer before, science is an essential player.

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Your body can synthesize vitamin D during exposure to the sun's UVB rays, but getting too much sun can raise your risk of skin cancer. Therefore, it may be best to boost your vitamin D levels by taking a daily supplement.

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Really great post.Vitamin D is essential to body function, especially during the winter months, when it is very difficult to obtain enough.The body needs this vitamin, and even if you feel horrible to know why recent studies show that may be due to the poor.It can handle a variety of disorders that can help transform the pain.

Bankruptcy said...

Well, informative article. The main function of vitamin D is to promote and regulate calcium absorption from food. Calcium is essential for a number of vital processes, including bone development, maintenance of several organ systems, and neurological function.

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I like to appreciate you for posting such nice informative information. It is such a very much valuable for me.

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Vitamin D is good for health.
The main function of vitamin D is to promote and regulate calcium absorption from food.

live healthCare said...

Yes Anna that's right I also agree with your point

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This is a great information for me.

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Now, DNA evidence that more vitamin D is an important player in heart health. When it was established that vitamin D receptors in the heart was no longer a matter of time before scientists began to laugh.

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Vitamin D receptor" existed in the affection it was alone a amount of time afore advisers began affliction out why attributes put it there.

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johnpoll said...

Vitamin D is maintain calcium balance.It is boost your immunity system.



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Vitamin D is very important for our body and health. It helps in many ways. It boosts immune system and helps a lot.

DNC said...

Yep, vitamin D is very useful if you want to lower high blood pressure and stay away from heart disease!

martindevid5 said...

Thanks for providing such a useful information about the vitamin D. It must be need to eat everyone.


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